The Centre of Research Excellence (CRE) to Reduce Inequality in Heart Disease focuses on improving the heart health and outcomes of groups and communities i.e. Regional Australians, Indigenous Australians and International Health

Doctor Yih-Kai Chan

Yih-Kai Chan is an early- to mid-career researcher working closely within an integrated portfolio of studies designed to develop, test and apply innovative, cost-effective health interventions across the continuum of heart disease, diabetes, obesity and nutrition. Yih-Kai received his PhD from the Proteomic and Biomedicine Research Group, Faculty of Medical and Health Science, the University of Auckland in 2008. His dissertation examined the role of transition metals and diabetogenesis and associated pathophysiological abnormalities and the use of potential copper chelation therapy with triethylenetetramine in managing diabetes mellitus.


Yih-Kai’s first post-doc position was at the Human Nutrition Unit, Auckland, NZ where he worked as a nutrition scientist on a number of novel functional food and nutrition discovery projects investigating their potential benefits to control appetite and satiety, thereby manage obesity and associated metabolic disorders. Yih-Kai has published more than 25 peer-reviewed papers in prestigious international journals. 


Yih-Kai is involved in the Regional Australians Research Stream of the CRE to study disease outcomes related to metabolic disorders and subsequent development of heart disease in regional communities. 

  1. Byrnes J, Carrington M, Chan YK, Pollicine C, Dubrowin N, Stewart S, Scuffham P. Cost-effectiveness of a home based intervention for secondary prevention of readmission with chronic heart disease. PLoS ONE 2015;10(12):e0144545.

  2. Poppitt SD, Han S, Strik CM, Kindleysides S, Chan YK. Investigating acute satiation and meal termination effects of a commercial lipid emulsion: A breakfast meal study. Physiol Behav 2015;152:20–25.

  3. Maru S, Joshua Byrnes J, Carrington MJ, Chan YK, Thompson DR, Stewart S, Scuffham PA. Cost-effectiveness of Home versus Clinic-Based Management of Chronic Heart Failure: Extended follow-up of a pragmatic, multicentre randomized trial cohort - The WHICH? Study (Which Heart Failure Intervention Is Most Cost-Effective & Consumer Friendly in Reducing Hospital Care).  Int J Cardiol 2015;201:368-375. 

  4. Stewart S, Chan YK, Wong C, Jennings G, Scuffham PA, Esterman A, Carrington MJ on behalf on the NIL-CHF Investigators. Impact of a nurse-led home and clinic-based secondary prevention program to prevent progressive cardiac dysfunction in high-risk individuals: The Nurse-led Intervention for Less Chronic Heart Failure (NIL-CHF) randomised controlled study. Eur J Heart Fail 2015;17:620-630.

  5. Betihavas V, Frost SA, Newton PJ, Macdonald P, Stewart S, Carrington MJ, Chan YK, Davidson PM. An Absolute Risk Prediction Model to Determine Unplanned Cardiovascular Readmissions for Adults with Chronic Heart Failure. Heart Lung Circ 2015;24(11)1068-1073.

  6. Chang S, Davidson PM, Newton PJ, Macdonald P, Carrington MJ, Marwick TH, Horowitz JD, Krum H, Reid C, Chan YK, Scuffham PA, Sibbritt, D, Stewart S. Composite outcome measures in a pragmatic clinical trial of chronic heart failure management: A comparative assessment Int J Cardiol 2015;185:62-68.

  7. Stewart S, Ball J, Horowitz JD, Marwick TH, Mahadevan G, Wong C, Abhayaratna WP, Chan YK, Esterman A, Thompson DR, Scuffham PA, Carrington MJ. Standard versus atrial fibrillation-specific management strategy (SAFETY) to reduce recurrent admission and prolong survival: pragmatic, multicentre randomised controlled trial. Lancet 2015;385(9970):775-784.

  8. Stewart S, Carrington MJ, Horowitz JD, Marwick TH, Newton PJ, Davidson PM, Macdonald P, Thompson DR, Chan YK, Krum H, Reid C, Scuffham PA. Prolonged impact of home versus clinic-based management of chronic heart failure: Extended follow-up of a pragmatic, multicentre randomized trial cohort. Int J Cardiol 2014;174(3):600-610.

  9. Chan YK, Mcgill AT, Kanwar RK, Krissansen GW, Haggarty N, Xin L, Poppitt SD. Bovine Peptic Casein Hydrolysate Ameliorates Cardiovascular Risk Factors in a Model of Apoe-Deficient Mice But Not Overweight, Mildly Hyper cholesterolaemic Men. Curr Res Nutr Food Sci 2014;2:08-19 .

  10. Carrington MJ, Chan YK, Stewart S, Sjouke B, Brazilek R, Cohen N. Long-term tolerance and efficacy of adjunctive exenatide therapy on glycaemic control and bodyweight in type 2 diabetes: a retrospective study from a specialist diabetes outpatient clinic. Internal medicine journal 2014;44:345-353.

  11. Carrington MJ, Chan YK, Calderone A, Scuffham PA, Esterman A, Goldstein S, Stewart S. A multicenter, randomized trial of a nurse-led, home-based intervention for optimal secondary cardiac prevention suggests some benefits for men but not for women: the Young at Heart study. Circulation Cardiovascular quality and outcomes 2013;6:379-389.

  12. Stewart S, Carrington MJ, Marwick TH, Davidson PM, Macdonald P, Horowitz JD, Krum H, Newton PJ, Reid C, Chan YK, Scuffham PA. Impact of home versus clinic-based management of chronic heart failure: the WHICH? (Which Heart Failure Intervention Is Most Cost-Effective & Consumer Friendly in Reducing Hospital Care) multicenter, randomized trial. J Am Coll Cardiol 2012;60:1239-1248.

  13. Chan YK, Strik CM, Budgett SC, McGill AT, Proctor J, Poppitt SD. The emulsified lipid Fabuless (Olibra) does not decrease food intake but suppresses appetite when consumed with yoghurt but not alone or with solid foods: A food effect study. Physiol Behav 2012;105:742-748.

  14. Chan YK, Stewart S, Calderone A, Scuffham P, Goldstein S, Carrington MJ. Exploring the potential to remain "Young @ Heart": Initial findings of a multi-centre, randomised study of nurse-led, home-based intervention in a hybrid health care system. Int J Cardiol 2012;154:52-58.

  15. Chan YK, Davis PF, Poppitt SD, Sun X, Greenhill NS, Krishnamurthi R, Przepiorski A, McGill AT, Krissansen GW. Influence of tail versus cardiac sampling on blood glucose and lipid profiles in mice. Lab Anim 2012;46:142-147.