The Centre of Research Excellence (CRE) to Reduce Inequality in Heart Disease focuses on improving the heart health and outcomes of groups and communities i.e. Regional Australians, Indigenous Australians and International Health


Research Stream:

Older Individuals with Chronic Heart Disease


Standard versus Atrial Fibrillation-spEcific managemenT studY is a secondary prevention, multi-centre randomised controlled trial that aims to optimise the management of patients with atrial fibrillation (AF) by improving delineation of individual risk factors over and above conventional risk profiling led by the Baker IDI. In collaboration with Co-Investigators from the University of Adelaide, University of Queensland, Griffith University, Menzies Institute (Tasmania), Australian National University and Australian Catholic University, we will utilise the outcomes of this profiling in combination with an AF-specific disease management program (DMP) involving advanced echocardiographic imaging, Holter monitoring and advanced platelet and endothelial function studies to direct and optimise the health status of a cohort of AF patients who have been hospitalised as a result of AF.


The NIL-CHF Study

The  Nurse-led Intervention for Less Chronic Heart Failure Study was a randomised trial exploring the potential to extend the proven benefits of multidisciplinary heart failure management programs to those at high risk of developing the syndrome.

WHICH? Trial

The Which Heart failure Intervention is most Cost-effective & consumer friendly in reducing Hospital care Trial was a multicentre randomised trial comparing two different forms of heart failure management to determine which is the best way to prolong survival and reduce hospital care for those affected by this often deadly and disabling condition.


Research Stream:

Regional Australians

The VIPER-BP Study

The Valsartan Intensified Primary carE Reduction of Blood Pressure Study was one of the largest contemporary studies involving more than 250 GPs and 2,185 uncontrolled hypertensive patients in primary care settings across Australia.

Healthy Hearts Beyond City Limits

Cardiovascular disease is consistently found to be more prevalent in regional and remote Australia compared to metropolitan areas. The aim of the Healthy Hearts Beyond City Limits program was to further explore these potential differentials to not only determine age and sex specific risk factor levels but the potential value of dedicated clinics to protect the heart health of regional communities.


Which Heart failure Intervention is most Cost effective in reducing Hospital care (WHICH? II) Trial: A multicentre, randomised trial of standard versus intensified management of metropolitan and regional-dwelling patients with heart failure.

Protecting Healthy Hearts

Protecting Healthy Hearts was a 6 month study to evaluate the benefits of a nurse-led, self-management intervention program for reducing risk factors for CVD and diabetes in a high risk, under-serviced population


Management to Optimise Diabetes and mEtabolic Risk reduction via Nurse-led intervention will develop a regional health care program that aims to reduce the risks of diabetes and cardiovascular disease for people in two Victorian regional towns (i.e. Shepparton and Colac).



Royal Flying Doctors Service (RFDS)

The Centre for Primary Care and Prevention partnered with the Royal Flying Doctor Service (RFDS) Victoria to undertake free cardiovascular and diabetes screening services for people living in regional and rural communities who are known to have poorer health outcomes and increased risk factors.



Diabetes Report

The Diabetes Report provides current data on the pattern of surveillance of blood glucose monitoring and management of diabetes over 9 years, in turn offering important clinical and public health messages for health professionals and the general public.


Research Stream:

International Health / Individuals living in low-to-middle income countrie


Heart of Soweto Study

While the burden of cardiovascular disease (CVD) states such as heart disease, is stabilising in high income countries, in low-to-middle income countries (LMIC) it continues to rise. With scarce health care resources, LMIC are typically ill-equipped to cope with new challenges when already over-burdened by illness related to malnourishment and infection. There is little scope to tackle new prototypes of heart disease arising from changing risk behaviours due to epidemiologic transition. Contemporary studies demonstrate high levels of non-communicable antecedents of heart disease (except dyslipidaemia) in sub-Saharan Africa; particularly urban communities.

It was within this context, that we established the now world-renowned Heart of Soweto – the largest and most comprehensive study of heart disease on the continent – focusing on presentations of heart disease to the Chris Hani Baragwaneth Hospital servicing the largest urban African community on the continent.


Protect-Africa study

Educational levels in young African women remain at historical lows. This provides a particular challenge when attempting to optimise the health of mothers and babies through educational strategies. It is estimated that up to one in two pregnant women in urban communities like Soweto are either overweight or obese. This poses a challenge to the heart health of both generations. In response, our group has pilot data showing the utility of an innovative information technology (IT)-based program to provide readily accessible and understandable health education to this vulnerable population.

Optimizing health outcomes in heart failure and multimorbidity: A multidisciplinary expert, consensus, scientific statement (Abridged Version)


Multimorbidity in heart failure (HF), defined by the presence of HF of any etiology and two or more concurrent conditions that require active management, represents a growing problem within the ageing HF patient population. Expert guidelines struggle to articulate how this multi-factorial problem can be effectively addressed – hence this initiative.

In recognising the complex clinical challenges inherent to managing HF in the setting of multimorbidity and the role of expert guidelines in providing a comprehensive overview of the relative strengths and applicability of treatment options, the specific aims of this Expert Consensus Statement were two-fold:

  1. To provide a comprehensive overview of the current literature focusing on the most common conditions requiring concurrent treatment and management in patients with HF.
  2. To derive a practical set of recommendations for a systematic response to this increasingly common clinical phenomenon.


Research Stream:

Indigenous Australians


Central Australia Heart Protection Study

Leading on from the Heart of the Heart Study and other surveillance trials led by Professor Brown, this ongoing study addresses high rates of death and disability associated with acute coronary syndrome (from unstable angina to acute myocardial infarction) in Central Australia.

Implementing cardiovascular standards to improve Indigenous cardiovascular care and outcomes 

This project will develop a framework for the implementation of cardiovascular standards, utilising the ESSENCE Standards, to improve cardiovascular care and outcomes for Aboriginal and Torres Strait Islander people.